Serologic biomarkers for acute mesenteric ischemic: a systematic review

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Author: Ting-Yu CHEN 1 Yi-Fan ZHAO 1 Chao ZHANG 1 Guo-Xiang TIAN 2

Affiliation: 1. Center for Evidence-Based Medicine, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, Hubei Province, China 2. Department of Geriatric Medicine, Seventh Medical Center of Chinese PLA General Hospital, Beijing 100700, China

Keywords: Acute mesenteric ischemic Serological biomarkers Clinical diagnosis Systematic review


Reference:Chen TY, Zhao YF, Zhang C, Tian GX. Serologic biomarkers for acute mesenteric ischemic: a systematic review[J]. Yixue Xinzhi Zazhi, 2021, 31(5): 374-382. DOI: 10.12173/j.issn.1004-5511.202010004.[Article in Chinese]

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Objective  To evaluate the effects of classical markers, novel serological biomarkers and other markers on the diagnosis of acute mesenteric ischemia (AMI). Methods  PubMed and Embase were searched by computer to collect and evaluate the studies on serum markers of AMI from the estab-lishment of the database to August 15, 2020. Qualitative induction was conducted for the included studies. Results  A total of 28 studies, including 5 meta-analysis, 7 prospective studies, 8 retrospective studies, 4 cross-sectional studies and 4 animal studies, were included. The speciality and sensitivity of classic markers (L-lactic acid, D-lactic acid and LDH) were low. The new serological biomarkers (D-dimer, platelet index, neutrophil-lymphocyte ratio, ischemia modifies albumin, 1-fatty acid binding protein, a-glutathione s-transferase, citruline) and other markers of AMI can be improved to some ex-tent, but the diagnostic value is still relatively limited. Conclusion  The diagnostic value of serum bi-omarkers of AMI is limited, and it is still difficult for those markers to be used to diagnose AMI in differ-ent types and stages. High-quality and large-sample studies are still needed to confirm it.

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1. Bala M, Kashuk J, Moore EE, et al. Acute mesenteric ischemia: guidelines of the world society of emergency surgery[J]. World J Emerg Surg, 2017, 12: 38. DOI: 10.1186/s13017-017-0150-5.

2. Kärkkäinen JM, Lehtimäki TT, Manninen H, et al. Acute mesenteric ischemia is a more common cause than expected of acute abdomen in the elderly[J]. J Gastrointest Surg, 2015, 19(8): 1407-1414. DOI: 10.1007/s11605-015-2830-3.

3. Clair DG, Beach JM. Mesenteric ischemia[J]. N Engl J Med, 2016, 374(10): 959-968. DOI: 10.1056/NEJMra1503884. 

4. Nuzzo A, Corcos O. Management of mesenteric ischemia in the era of intestinal stroke centers: the gut and lifesaving strategy[J]. Rev Med Interne, 2017, 38(9): 592-602. DOI: 10.1016/j.revmed.2017.01.018. 

5. Lawson RM. Mesenteric ischemia[J]. Crit Care Nurs Clin North Am, 2018, 30(1): 29-39. DOI: 10.1016/j.cnc.2017. 10.003.

6. Ehlert BA. Acute gut ischemia[J]. Surg Clin North Am, 2018, 98(5): 995-1004. DOI: 10.1016/j.suc.2018.06.002.

7. Tilsed JV, Casamassima A, Kurihara H, et al. ESTES guidelines: acute mesenteric ischaemia[J]. Eur J Trauma Emerg Surg, 2016, 42(2): 253-270. DOI: 10.1007/s00068-016-0634-0.

8. Cudnik MT, Darbha S, Jones J, et al. The diagnosis of acute mesenteric ischemia: a systematic review and meta-analysis[J]. Acad Emerg Med, 2013, 20(11): 1087-1100.DOI: 10.1111/acem.12254.

9. Treskes N, Persoon AM, van Zanten ARH. Diagnostic accuracy of novel serological biomarkers to de-tect acute mesenteric ischemia: a systematic review and meta-analysis[J]. Intern Emerg Med, 2017,12(6): 821-836. DOI: 10.1007/s11739-017-1668-y.

10. Sun DL, Li SM, Cen YY, et al. Accuracy of using serum D-dimer for diagnosis of acute intestinal ische-mia: a meta-analysis[J]. Medicine (Baltimore), 2017, 96(13): e6380. DOI: 10.1097/MD.0000000000006380.

11. Beyan C, Beyan E. Were the measurements standardized sufficiently in published studies about mean platelet volume?[J]. Blood Coagul Fibrinolysis, 2017, 28(3): 234-236. DOI: 10.1097/MBC.0000000000000586.

12. Khan SM, Emile SH, Wang Z, et al. Diagnostic accuracy of hematological parameters in acute mesen-teric ischemia-a systematic review[J].  Int J Surg, 2019, 66: 18-27. DOI: 10.1016/j.ijsu.2019.04.005.

13. Hong J, Gilder E, Blenkiron C, et al. Nonocclusive mesenteric infarction after cardiac surgery: potential biomarkers[J]. J Surg Res, 2017, 211: 21-29. DOI: 10.1016/j.jss.2016.12.001.

14. Block T, Nilsson TK, Björck M, et al. Diagnostic accuracy of plasma biomarkers for intestinal ischae-mia[J]. Scand J Clin Lab Invest, 2008, 68(3): 242-248. DOI: 10.1080/00365510701646264.

15. Kulu R, Akyildiz H, Akcan A, et al. Plasma citrulline measurement in the diagnosis of acute mesenteric ischaemia[J]. ANZ J Surg, 2017, 87(9): E57-E60. DOI: 10.1111/ans.13524.

16. Uzun O, Turkmen S, Eryigit U, et al. Can intestinal fatty acid binding protein (I-FABP) be a marker in the diagnosis of abdominal pathology?[J]. Turk J Emerg Med, 2016, 14(3): 99-103. DOI: 10.5505/1304.7361.2014.15679.

17. Güzel M, Sözüer EM, Salt Ö, et al. Value of the serum I-FABP level for diagnosing acute mesenteric ische-mia[J]. Surg Today, 2014, 44(11): 2072-2076. DOI: 10.1007/s005 95-013-0810-3.

18. Sekino M, Funaoka H, Sato S, et al. Intestinal fatty acid-binding protein level as a predictor of 28-day mortality and bowel ischemia in patients with septic shock: a preliminary study[J]. J Crit Care, 2017, 42: 92-100. DOI: 10.1016/j.jcrc.2017.07.012.

19. Gearhart SL, Delaney CP, Senagore AJ, et al. Prospective assessment of the predictive value of al-pha-glutathione S-transferase for intestinal ischemia[J]. Am Surg, 2003, 69(4): 324-329. DOI: 10.1034/j.1600-6143.2003.00066.x.

20. Ambe PC, Kang K, Papadakis M, et al. Can the preoperative serum lactate level predict the extent of bowel ischemia in patients presenting to the emergency department with acute mesenteric ische-mia?[J]. Biomed Res Int, 2017, 2017: 8038796. DOI: 10.1155/2017/8038796.

21. Yang K, Wang W, Zhang WH, et al. The combination of D-dimer and peritoneal irritation signs as a potential indicator to exclude the diagnosis of intestinal necrosis[J]. Medicine (Baltimore), 2015, 94(40): e1564. DOI: 10.1097/MD.0000000000001564.

22. Aktimur R, Cetinkunar S, Yildirim K, et al. Neutrophil-to-lymphocyte ratio as a diagnostic biomarker for the diagnosis of acute mesenteric ischemia[J]. Eur J Trauma Emerg Surg, 2016, 42(3): 363-368. DOI: 10.1007/s00068-015-0546-4.

23. Degerli V, Ergin I, Duran FY, et al. Could mean platelet volume be a reliable indicator for acute mes-enteric ischemia diagnosis? A case-control study[J]. Biomed Res Int, 2016, 2016: 9810280. DOI: 10.1155/2016/9810280.

24. Gunduz A, Turedi S, Mentese A, et al. Ischemia-modified albumin in the diagnosis of acute mesenteric ischemia: a preliminary study[J]. Am J Emerg Med, 2008, 26(2): 202-205. DOI: 10.1016/j.ajem.2007.04.030.

25. Kanda T, Fujii H, Tani T, et al. Intestinal fatty acid-binding protein is a useful diagnostic marker for mesenteric infarction in humans[J]. Gastroenterology, 1996, 110(2): 339-343. DOI: 10.1053/gast.1996.v110.pm8566578.

26. Crenn P, Messing B, Cynober L. Citrulline as a biomarker of intestinal failure due to enterocyte mass reduction[J]. Clin Nutr, 2008, 27(3): 328-339. DOI: 10.1016/j.clnu. 2008.02.005.

27. Rosero O, Harsányi L, Szijártó A. Acute mesenteric ischemia: do biomarkers contribute to diagnosis?[J]. Orv Hetil, 2014, 155(41): 1615-1623. DOI: 10.1556/OH.2014.30013.

28. Smith SM, Eng RH, Campos JM, et al. D-lactic acid measurements in the diagnosis of bacterial infec-tions[J]. J Clin Microbiol, 1989, 27(3): 385-388. DOI: 10.1128/jcm. 27.3.385-388.1989.

29. Oh MS, Phelps KR, Traube M, et al. D-lactic acidosis in a man with the short-bowel syndrome[J]. N Engl J Med, 1979, 301(5): 249-252. DOI: 10.1056/NEJM1979080230 10505.

30. Czuczejko J, Mila-Kierzenkowska C, Szewczyk-Golec K. Plasma α-glutathione S-transferase evaluation in patients with acute and chronic liver injury[J]. Can J Gastroenterol Hepatol, 2019, 2019: 5850787. DOI: 10.1155/2019/ 5850787.

31. Kim KY, Lee HK, Kim H, et al. Stromal cell-derived factor-1 as a serologic biomarker for the diagnosis of colon ischemia with chronic cardiovascular disease[J]. Medicine (Baltimore), 2020, 99(23): e20539. DOI: 10.1097/MD.0000 000000020539.

32. Lapsekili E, Menteş Ö, Balkan M, et al. Role of alkaline phosphatase intestine-isomerase in acute mes-enteric ischemia diagnosis[J]. Ulus Travma Acil Cerrahi Derg, 2016, 22(2): 115-120. DOI: 10.5505/tjtes.2015.49475.

33. Acar T, Koçak S, Cander B, et al. Liporotein-associated phospholipase-A2 can be a diagnostic marker inthe early stage diagnosis of acute mesenteric ischemia[J]. Turk J Med Sci, 2016, 46(1): 120-125. DOI: 10.3906/sag-1412-29.

34. Schellekens DH, Reisinger KW, Lenaerts K, et al. SM22 a plasma biomarker for human transmural in-testinal ischemia[J]. Ann Surg, 2018, 268(1): 120-126. DOI: 10.10 97/SLA.0000000000002278.

35. Lebrun LJ, Grober J. Could glucagon-like peptide-1 be a potential biomarker of early-stage intestinal ischemia?[J].Biochimie, 2019, 159: 107-111. DOI: 10.1016/j.biochi. 2018.11.009.

36. Montagnana M, Danese E, Lippi G. Biochemical markers of acute intestinal ischemia: possibilities and limitations[J]. Ann Transl Med, 2018, 6(17): 341. DOI: 10.21037/atm.2018.07.22.

37. Yang S, Fan X, Ding W, et al. D-dimer as an early marker of severity in patients with acute superior mesenteric venous thrombosis[J]. Medicine (Baltimore), 2014, 93(29): e270. DOI: 10.1097/MD.0000000000000270.

38. Coskun AK, Halici Z, Oral A, et al. The value of combined elevation of D-dimer and neopterin as a pre-dictive parameter for early stage acute mesenteric ischemia: an experimental study[J]. Vascular, 2017, 25(2): 163-169. DOI: 10.1177/1708538116652267.

39. Ludewig S, Jarbouh R, Ardelt M, et al. Bowel ischemia in ICU patients: diagnostic value of I-FABP de-pends on the interval to the triggering event[J]. Gastroenterol Res Pract, 2017, 2017: 2795176. DOI: 10.1155/2017/2795176.

40. Matsumoto S, Shiraishi A, Kojima M, et al. Comparison of diagnostic accuracy for nonocclusive mes-enteric ischemia in models with biomarkers including intestinal fatty acid-binding protein in addition to clinical findings[J]. J Trauma Acute Care Surg, 2019, 86(2): 220-225. DOI: 10.1097/TA. 0000000000002100.

41. Sahin A, Altay DA, Demir S, et al. Comparison of the diagnostic values of vascular adhesion protein-1 and intestinal fatty acid-binding protein in the diagnosis of acute mesenteric ischemia[J]. Eur J Trauma Emerg Surg, 2019, 45(3): 545-553. DOI: 10.1007/s00068-018-0944-5.

42. Destek S, Yabacı A, Abik YN, et al. Predictive and prognostic value of L-lactate, D-dimer, leukocyte, C-reactive protein and neutrophil/lymphocyte ratio in patients with acute mesenteric ischemia[J]. Ulus Travma Acil Cerrahi Derg, 2020, 26(1): 86-94. DOI: 10.14744/tjtes.2019.61580.

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