Advances in the study of biological agents in the treatment of Crohn’s disease

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Author: Han-Han ZHENG 1, 2 Xue-Liang JIANG 3

Affiliation: 1. Department of Gastroenterology, Shandong Police General Hospital, Jinan 250000, China 2. Department of Gastroenterology, Shandong Nanshan Hospital, Jinan 250000, China 3. Department of Gastroenterology, the Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250001, China

Keywords: Crohn’s disease Biological agents Treatment


Reference:Zheng HH, Jiang XL. Advances in the study of biological agents in the treatment of Crohn's disease. DOI: 10.12173/j.issn.1004-5511.202011054.[Article in Chinese]

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Crohn’s disease (CD) is a chronic, non-specific intestinal inflammatory disease. A large number of clinical trials have shown that biological agents are effective in inducing remission in patients with CD, and mainte-nance treatment can achieve long-term remission. At present, biological agents are now being widely used in the treatment of CD and have become the main treatment. These include the anti-tumor necrosis factor (TNF)-α monoclo-nal antibodies, anti-integrin antibody, IL-12/23 monoclonal antibody and a Janus kinase (JAK) inhibitor. In this article, we review the progress and selection of biologics in the treatment of CD.

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